• Parisa Zamiri Thumb

    A Personal Quest to Prevent Blindness (Video)

    A family member’s suffering motivates translational medicine expert Parisa Zamiri to find treatments for ophthalmologic diseases. Her current research focus is dry age-related macular degeneration, a significant cause of blindness in older people worldwide.

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    A “Swell” discovery on how cells keep in shape

    The Cell cover illustration depicts a normal and a swollen cell as artworks in a museum: one small and dwarfed by a dense, wrinkly frame and the other large and smooth. The cover was designed by the illustrator Jorge Colombo using finger painting on an iPad. The GNF scientists admired his work in the New Yorker and contacted him to illustrate their paper in Cell about how cells sense their environment.

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    Addressing Cognitive Symptoms of Schizophrenia Through a Nicotinic Acetylcholine Receptor Alpha 7 Partial Agonist

    NIBR researchers led by Konstanze Hurth (global discovery chemistry) and Dominik Feuerbach (neuroscience) set about looking for something that could help patients suffering from Schizophrenia with daily functioning and social integration.

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    Collaborating to unravel clues about neuropsychiatric diseases

    NIBR teams up with the Broad Institute to lay a foundation for rational drug discovery in autism, schizophrenia, and other brain disorders.

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    Scientific Renewal Keeps Discoveries Flowing

    NIBR scientists embark on mini-sabbaticals to acquire new skills and perspective.

  • SimpleShow - Rare Diseases

    What’s all this talk about rare disease?

    The size of the patient population does not drive our research. Do we understand the science? Is there is unmet medical need? Those are the questions the Novartis Institutes for BioMedical Research asks. Surprising for a Pharma Organization? Not really. Here’s why.

  • sIBM patient Charlie Cleaves

    Rare Disease - Focus on the patient, follow the science

    Sporadic inclusion body myositis (sIBM) is the most common acquired muscle disease of people over 50 and has no approved treatment. Finding therapies for rare disease flows from our desire to help patients underserved by today’s medicines.

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    Rare Diseases Beyond the Numbers

    Novartis Institutes for BioMedical Research created this interactive quiz, hoping that testing people’s knowledge of rare diseases would help them understand the great need for new treatment options for patients with rare diseases.

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    Toward precision medicine for a rare blood cancer

    Novartis has joined forces with lymphoma experts in academia to hack into the genetics of a rare form of blood cancer known as mantle cell lymphoma (MCL). Working with lymphoma experts from Charité – Universitätsmedizin in Berlin and the BC Cancer Research Centre in Vancouver, Canada, Novartis scientists provide evidence of two related but mutually exclusive molecular signaling pathways at play in MCL cell lines.

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    A rare disease, a challenging clinical trial

    Cushing’s is a rare disease that affects only about 10 to 15 people per million. It is difficult to diagnose and can make clinical trials for such a small patient population very challenging. But finding treatments for patients with few options is at the heart of our approach. Learn more about one trial and the scientists and patients who made it work.

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    Letters To My Younger Self - Renee Bergeron

    “I was always planning and very deliberate. I look back now and wish I hadn’t been so deliberate…” Renee Bergeron writes to herself at the age of 38, on her first day back in the office following the birth of her first daughter.